COMBINATION OF CRIZOTINIB AND OSIMERTINIB IN T790M+ EGFR-MUTANT NON-SMALL CELL LUNG CANCER WITH EMERGING MET AMPLIFICATION POST-OSIMERTINIB PROGRESSION IN A 10-YEAR SURVIVOR: A CASE REPORT

Tyrosine kinase inhibitors (TKIs) represent the standard Studs treatment for patients with non-small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) mutations.The duration of the response is, however, limited in time owing to the development of resistance mechanisms to both first- and second-generation agents such as MET

The primary purpose of this research is to find out how memorable tourism experiences influence revisit intention and recommendation intention of tourists who have visited to enjoy historical tourism and taste Rajamangsa local cuisine in Kebondalem Kidul Cultural Tourism Village, with destination image and satisfaction as mediating factors.This res

Electronic voting systems have often associated with issues of security, transparency, and limited accessibility, particularly Chains for people with disability, elderly, and visually impaired voters.These systems, impeded by complex authentication procedures and non-intuitive user interfaces, have also struggled to ensure voter trust and widesprea

The efficient analysis of digital mammograms has an important role in the early detection of breast cancer and can lead to a higher percentage of recovery.This paper presents an extended computer-aided diagnosis system for the classification of mammograms into three classes (normal, benign and malignant).The performance of the system is evaluated f

Kouichi Ohta, Atsuko Sato, Nami Senda, Emi Fukui Department of Ophthalmology, Matsumoto Dental University, Nagano, Japan Background: We have shown that the foveal contour was asymmetrical after idiopathic macular hole (MH) closure by pars plana vitrectomy (PPV) with internal limiting membrane (ILM) peeling.The purpose of this study was to determine